1. DuraGen® Plus Adhesion Barrier Matrix is a resorbable implant for repairs and restoration of dural defects.

2. It is an adhesion barrier for the reduction of Peridural Fibrosis.

3. The extra space allows the surgeon to tuck the matrix under the lamina.

4. After the placement, DuraGen® Plus conforms via surface tension within 10 minutes and fibrin clot formation will begin, and post 24 hours, a water-tight fibrin seal is formed¹.

5. Usage of DuraGen® Plus over weak suture lines and pinholes as an adjunct, helps prevent CSF leakage², especially in the cases where the chances of CSF leakage are high.

Reference:

1. Data on file   2. Stendel R, Danne M, Fiss I, Klein I, Schilling A, Hammersen S, Pietilae T, Jänisch W, Hopfenmüller W. Efficacy and safety of a collagen matrix for cranial and spinal dural reconstruction using different fixation techniques. Journal of neurosurgery. 2008 Aug 1;109(2):215-21.

1. DuraGen® Plus is used by neurosurgeons, post an operation to cover the dural defects caused by the surgery.

2. It works as a scaffold and forms a new layer of Dura mater under the scalp1.

3. DuraGen® Plus reduces the chances of CSF leakage2 post-surgery and saves OT time by 45-55 minutes with the onlay and inlay technique3,4.

4. It reduces the mean post-operative pain scores along with cranial and spinal complications2.

5. It lowers the time and the cost of the treatment4,5.

References:

1. NAROTAM PK, et al. A clinicopathological study of collagen sponge as a dural graft in neurosurgery. J Neurosurg 82:406–412, 1995. Prospective study (post mortem or during reoperation) performed on a 5 years period, on 100 patients who received a collagen implant. 2. Stendel R, Danne M, Fiss I, Klein I, Schilling A, Hammersen S, Pietilae T, Jänisch W, Hopfenmüller W. Efficacy and safety of a collagen matrix for cranial and spinal dural reconstruction using different fixation techniques. Journal of neurosurgery. 2008 Aug 1;109(2):215-21. 3. Arrotegi I. Reduction of clinical symptoms after lumbar discectomy using Collagen Dural Matrix clinical trial. World Spinal Column J. 2011;2(1):7-11. 4. Horaczek JA, Zierski J, Graewe A. Collagen matrix in decompressive hemicraniectomy. Operative Neurosurgery. 2008 Jul 1;63(suppl_1):ONS176-81. 5. Barooah RK, Baishya BK, Haloi H, Bhuyan M, Ali A, Sarma K. A Comparative Study between Autologous Dural Closure versus Collagen Matrix (DuraGen) Closure in Decompressive Craniectomy for Trauma. Indian Journal of Neurotrauma. 2020 Jun;17(01):46-9.