Alfoo

01 / 03

Alfoo is the No. 1 Prescribed Brand for Sexually Active Males with LUTS

Why Alfoo? Mode of Action of Alfuzosin Usage What are the Side Effects Safety Advice

Why Alfoo?

Alpha-blockers are used in the management of LUTS due to Benign Prostatic Hyperplasia (BPH). However, they are likely to cause Ejaculatory Dysfunction (EjD).

Alfoo improves Lower Urinary Tract Symptoms (LUTS) due to BPH with minimal effect on the Ejaculatory Function.1

1. Van Moorselaar RJ et al. ALF-ONE Study Group. Alfuzosin 10 mg once daily improves sexual function in men with lower urinary tract symptoms and concomitant sexual dysfunction. BJU Int. 2005 Mar;95(4):603-8.

Mode of Action of Alfuzosin

The smooth muscle tone is regulated by alpha-adrenergic receptors.

Blockade of these adrenoreceptors results in smooth muscle in the bladder neck and prostate to relax, further resulting in an improvement in urine flow and a reduction in symptoms of LUTS due to BPH.

Alfuzosin is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.2

Alfuzosin’s α1-uroselectivity seems to produce less EjD compared to its counterparts that also affect vascular smooth muscle tone.3

2. Mari A et al. Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis. Ther Adv Urol. 2021 Apr 12;13:1756287221993283. 3. Haywood E. L. Yeung, et al: Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. World J Mens Health. 2021 Apr;39(2):186-194.

Usage4

Alfuzosin is used for the treatment of symptomatic BPH.

The recommended dosage is 10 mg Alfuzosin daily to be taken immediately after the same meal each day. The tablets should not be chewed or crushed.

4. Product information Alfuzosin

What are the Side Effects?4

Postural Hypotension with or without symptoms (e.g. dizziness) may develop within a few hours following administration of Alfuzosin. As with all alpha-blockers, there is a potential for syncope.

IFIS observed during cataract surgery in some patients on or previously treated with alpha-1 blockers.

The risk of this event with Alfuzosin appears very low.

Ophthalmic surgeons should be informed in advance of cataract surgery of current or past use of alpha-1-blockers as IFIS may lead to increased procedural complications.

The Ophthalmologists should be prepared for possible modifications to their surgical technique.

IFIS: Intraoperative Floppy Iris Syndrome

4. Product information Alfuzosin

Safety Advice4

Patients should be warned of the possible occurrence of syncope and should avoid situations where injury could result in syncope. Care should be taken when Alfuzosin is administered to patients with symptomatic Hypotension or patients who have had a hypotensive response to other medications.

Alfuzosin HCl is contraindicated:

In patients with moderate or severe hepatic insufficiency

When administered with potent CYP3A4 inhibitors and therefore, should not be used in combination with drugs such as Ketoconazole, Itraconazole and Ritonavir.

Pregnancy and Lactation

Known hypersensitivity to Alfuzosin or any other ingredients of the formulation

History of Orthostatic Hypotension

4. Product information Alfuzosin

Knowledge Hub

Alfuzosin shows improvement of LUTS without affecting Ejaculatory function

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Alfuzosin shows improvement.pdf
Alfuzosin’s similar efficacy to Tamsulosin in managing LUTS due to BPH

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Alfuzosins similar efficacy.pdf
Alfuzosin exerts clinically remarkable improvements than Tamsulosin

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Alfuzosin exerts clinically remarkable.pdf
Effects of acute treatment with Tamsulosin Versus Alfuzosin on Ejaculatory Function

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Comparison of Alfuzosin.pdf
Comparison of Alfuzosin and Tamsulosin for treatment of lower urinary tract symptoms

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Comparison of Alfuzosin_0.pdf